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Moreover, the number of senescent cells also increase with culture time, resulting in a loss of division capabilities, resistance to apoptosis, and the acquisition of a robust proinflammatory secretome known as the senescence-associated secretory phenotype (SASP) (Jeon et al., 2018)
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Stem Cells 35 (6), 14461460
As lentigo malignas often present on severely sun-damaged skin, it is frequently found amongst numerous pigmented lesions thin seborrheic keratoses, lentigo senilis, lentigines
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and (4) the 2-oxoadipate dehydrogenase complex, all of which share the same architecture
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