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MacGillivray, M.H
Harvard Women's Health Watch Reviewed by Meghan Salamon, MS, RDN, LDN, CPT, Contributor After a year of using a GLP-1 medication to lose weight, Abby was ecstatic to have shed more than 100 pounds
GLP-1 agonists, or medications, mimic the hormone theyre named afterglucagon-like peptide-1that stimulates the body to release insulin when blood sugar levels start to rise
IL-4 shapes microglia-dependent pruning of the cerebellum during postnatal development
Why GLP-1s are Biologically Plausible for Alzheimers Beyond lowering glucose and weight, GLP-1 signaling appears to: Improve insulin signaling in the brain Dampen neuroinflammation (microglial activation) Reduce oxidative stress Interact with amyloid- and tau pathways in preclinical models Recent peer-reviewed reviews synthesize these mechanisms and frame GLP-1s as potential multi-target neuroprotective agents rather than single-pathway drugs
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