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Ultimately, 27 studies met our inclusion criteria for the systematic review

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Incretin-based anti-obesity medications The development of next-generation AOMs, such as incretin-based GLP-1 receptor agonists, offers promising potential for reducing the health impacts of obesity and improving overall public health outcomes

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We compared a 6 and 12-month change in total body weight loss (TBWL) for those receiving monotherapy from the initiation of GLP-1 analogue therapy with those receiving combination therapy from the initiation of bupropion/naltrexone added-on therapy