does glp 1 cause depression GLP-1s: Are We Ignoring the Psychiatric Risks? GLP-1s and Depression: What the

Studies show the peptide markedly decreases activation of astrocytes and microgliathe brain's primary immune cells whose chronic activation contributes to neurodegeneration

Biomark Res (2020) 8:38

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In humans, where C-cell GIP receptor expression appears to be lower, this effect may be minimal GIP and thyroid blood flow: Some preclinical data suggest GIP influences thyroid gland blood flow, which could theoretically affect hormone production and levothyroxine absorption in patients with remaining thyroid tissue No adverse thyroid effects in trials: In the SURMOUNT and SURPASS clinical trials, tirzepatide did not produce clinically significant changes in thyroid function tests in participants with normal thyroid function The presence of GIP receptors on thyroid tissue is an area of active research

For some patients, its the main reason they decline or hesitate in deciding on injectable treatments