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Even though the proportion of patients becoming non-self-sufficient is now a validated endpoint for trials in ALS [9], we decided to use the overall survival as primary endpoint based on the results from a previous clinical trial [11]
We would go do our research on them, and you find out there's a ton of amazing anecdotal evidence on it. Physicians themselves have flexibility in what they prescribe, he explained
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without a dose matrix, they cannot distinguish additivity from synergy
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