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Transplanting embryonic stem cell-derived astrocytes into murine ALS models with the SODG93A mutation has been found to restore young astrocyte characteristics, potentially slowing disease progression 131
This structural change significantly lowers its affinity for IGF-binding proteins (IGFBPs), leading to a much longer half-life (approx
Although mechanistic studies are needed to confirm that Nrf2-mediated responses are at play when -synuclein is overexpressed in our model, Lastres-Becker et al
If the research protocol is in mcg and the vial is in mg, the conversion is essential
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