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NICE first recommended the drug in draft guidance 2022, after a clinical trial of just under 2000 volunteers found that people lost on average 12% more weight with semaglutide alongside supervised weight loss coaching (BMJ 2023;380:556)

By starting with lower doses and building up gradually, patients are able to adapt to the drug, reducing dropout rates and improving long-term tolerability a dosing philosophy shared with semaglutide and tirzepatide protocols

WILMINGTON, DE, May 07, 2026 (GLOBE NEWSWIRE) -- DISCLAIMER: This article is for informational and educational purposes only and does not constitute medical advice

Months three through six represent the most dramatic transformation window

Your body may be losing fat while gaining muscle, retaining water, or adjusting glycogen storesall of which affect the scale differently than visible fat loss