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Notably, DPP-4 inhibitors appear to be safe regarding the risk of fractures, as they tend to decrease this risk, but more clinical trials are needed to explore the effects of DPP-4 inhibitors in other populations beyond T2DM
Clinical trials have documented modest heart rate increases averaging 2-4 beats per minute, though some patients may experience larger increases
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Additionally, besides its effective role in weight reduction, tirzepatide has demonstrated improvements in cardiovascular metabolic risk factors
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