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In adults with biopsy-confirmed metabolic dysfunction-associated steatohepatitis (MASH) and stage 2 or 3 fibrosis, semaglutide 2.4 mg achieved MASH resolution without fibrosis worsening in 62.9% of treated patients versus 34.3% on placebo at 72 weeks
This causes acute liver injury, elevated liver enzymes, jaundice, and potential acute liver failure if severe
Skin and Other Effects: Very rarely, severe skin rashes or abdominal pain have been reported
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