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At the end of day 10, blood samples were drawn and liver and kidney tissues were removed
The supernatant was used to detect antioxidant biomarkers, such as the glutathione (GSH), total antioxidant capacity (T-AOC), content and malondialdehyde (MDA) levels, according to the manufacturers instructions (Nanjing Jiancheng Bioengineering Institute, Nanjing, China)
Instead, our findings demonstrate an important role for GSH in the liver, where under resting conditions, GSH maintains low NRF2 activity to permit ample expression of lipogenic enzymes, promotes the production of triglycerides, and sustains lipid abundance in vivo
More clinical research is needed to fully characterize its efficacy and safety profile
However, because standard oral glutathione is poorly absorbed by the gut, the delivery methodsuch as liposomal technologyis often more important than the raw dose
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