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Getting shots often is usually needed to quickly raise B12 levels
Its efficacy when topically applied on skin has not been adequately studied
But as explained above, the hyaluronic acid used in these injections is derived from the combs of roosters
Such a mechanism could theoretical be mediated by the oncoprotein MDM2, which interacts with p53 but has recently also been found to associate with certain cell surface receptors and regulate their functions (Shenoy et al, 2001)
Shots are often used for those with pernicious anemia or trouble absorbing B12
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