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However, these models have faced challenges in reproducing the wide range of symptoms observed in human HFpEF, since usually one organ system is targeted and the pathology is replicated in a relatively acute setting in comparison to the natural course of HFpEF in humans
In addition, age dependent accretion of dysfunctional mitochondria elevates stress level, which is exhibited by high levels oxidized products such as protein carbonyls and lipid peroxides 42
Histamine also has a circadian rhythm and is what keeps us awake
doi:10.4161/epi.25798
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