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Lustigs key points was that obesity is not the cause of metabolic dysfunction, added sugar is

Patients using heat-compromised semaglutide may notice: Unexplained rises in blood glucose levels despite adherence to the dosing schedule Return of appetite or reduced satiety between doses Weight loss plateau or weight regain without changes in diet or activity These clinical signs suggest reduced medication potency and warrant discussion with your healthcare provider

Zheng S, Zhang Y, Long T, Lu J, Liu X, Yan J, et al

PMID: 9879640 | doi:10.1080/004982598238976 Jett L et al

Detoxification : The liver is the bodys primary detoxification organ, responsible for processing and eliminating toxins and metabolic waste products