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If eGFR is below 45, cap magnesium at 200 mg elemental/day and check kidney function and magnesium at 4 to 6 weeks

C ssmin = (C -48h + C -24h + C 0h )/3

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Symptoms of Biotin Deficiency Hair loss or alopecia, depression, lethargy, hallucinations, numbness and tingling in the hands and feet, a scaly, red rash around the eyes, nose and mouth, seizures, weakened immune system, increased risk of bacterial and fungal infections

Further research is needed to validate molecular pathways, assess long-term safety and efficacy, and confirm causal relationships through advanced mechanistic and physicochemical analyses