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R., Ritchie, S., Pereira, B
Altered GH-IGF-1 axis in severe obese subjects is reversed after bariatric surgery-induced weight loss and related with low-grade chronic inflammation
Mechanisms and disease consequences of nonalcoholic fatty liver disease
During its brief time in circulation, it rapidly engages cell receptors (like the Growth Hormone Receptors) and activates key signaling pathways (like the Akt-eNOS pathway) that initiate a long-lasting, sustained genetic expression program for tissue repair
Furthermore, the impact of metformin on glucose uptake in the digestive system is associated with the amount of GLUT2 expression, rather than relying on GLUT2 expression in the intestinal lining (Morrice et al., 2023)
