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Complementing this primary mechanism, emerging evidence indicates that SFN modulates iron metabolism through upregulation of ferritin heavy chain (FTH1), potentially altering intracellular iron homeostasis to promote iron-mediated lipid peroxidation via Fenton chemistry (69, 70)

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Moreover, treatment allocation was not randomized and may have been influenced by baseline metabolic severity, thereby introducing potential confounding by indication

(Diabetes Care, 2022) found that patients prescribed semaglutide for weight management achieved 12.1% average weight loss at 12 months, while those prescribed Contrave achieved 4.8% weight loss over the same period

Selenium supplementation and male fertility: Mechanistic insights and therapeutic potential