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When the body is in a state of hypoxia, infection, intense exercise, etc, and the cells demand for ATP increases, pyruvate and NADH tends to be directly catalyzed by lactate dehydrogenase (LDH) to produce lactate, rather than entering the mitochondria to participate in the tricarboxylic acid cycle (TCA)

doi: 10.1016/j.intimp.2020.107061 250 YangSYinWDingYLiuF

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Avoid vigorous agitation

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