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Although EECs might sense nutrients via activation of specific GPCRs on the apical side, where they are in direct contact with the luminal environment, elegantly performed ex vivo and in vitro studies suggest that many nutrients, including fatty acids, may be detected on the basolateral surface 17,93,94

However, the absence of a documented interaction does not necessarily establish the safety or efficacy of this combination

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While various cell membrane lipids may undergo oxidation, the peroxidation of polyunsaturated fatty acids (PUFAs) in phospholipids by lipoxygenases (ALOXs) appears to be particularly important for ferroptosis [23]

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