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When the conversion of propionyl-CoA to succinyl-CoA in the mitochondria fails due to Vitamin B 12 deficiency, elevated blood levels of methylmalonic acid (MMA) occur

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Melanin index measurements (via Mexameter MX18) showed mean reduction of 18.7% in the treatment group versus 3.2% placebo

Finally, the heterogeneity of the different disease states and checkpoint inhibitors included in our study hampers our ability to compare our results with other studies that focus on a specific disease state or on a specific checkpoint inhibitor agent