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Abstract 2,4-Dinitrophenol (DNP) is an artificial mitochondrial uncoupler that was used as an anti-obesity treatment until it was withdrawn due to high toxicity, a narrow therapeutic window, and a lack of an antidote
It is normally conjugated by glutathione (GSH), but when taken in excess, the body's glutathione reserves are not sufficient to deactivate the toxic NAPQI
Rhen, T., & Cidlowski, J
Mahaffey et al
NLRP3 inflammasome in acute myocardial infarction
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