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Although biochemically separated from the GSH system, the Trx system shares NADPH as a common reducing cofactor and serves as an alternative pathway for reducing disulfide bonds, making this system especially relevant if the GSH system has been compromised or rendered dysfunctional (Silva-Adaya et al., 2014)
Other common symptoms include regurgitation of food or sour liquid, difficulty swallowing, chronic cough, a sensation of a lump in the throat, and disrupted sleep due to discomfort
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Therefore, it seems that the reduction of serum CRP levels in affected patients can probably be promising in reducing some complications of the disease, such as cardiovascular risks
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