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However, in resistant patients, oxidative stress causes a conformational change in Keap1, leading to the release of NRF2, which translocates to the nucleus and binds to antioxidant response element (ARE), activating the expression of downstream antioxidant genes, including GPX4, NQO1, HO-1 and SOD1 [33], and promoting the synthesis of GSH, as illustrated in Fig
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6 This suggests that glutathiones antioxidative properties can directly interfere with the viral life cycle, potentially reducing the severity and duration of cold sore outbreaks
Similarly, in sorghum, aged seeds often exhibit reduced growth rates and increased susceptibility to fungal pathogens, further compromising crop performance ( Seed vigor and longevity are complex quantitative traits governed by multiple genes with minor effects, often influenced by environmental interactions (Kannababu et al., 2025)
