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For example, nuclear IGF-IR phosphorylates proliferating cell nuclear antigen at Y60/133/250 and promotes its ubiquitination, which prevents replication fork stalling after DNA damage [89]

Metformin Metformin is a first-line treatment for type 2 diabetes that also exhibits anti-aging effects by activating AMP-activated protein kinase (AMPK)

elegans strains used in this work

But the trial data indicates regain is the more common outcome, and planning around the less common one carries obvious risk