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Key Takeaway: Tirzepatide works by mimicking two hormones (GIP and GLP-1) to help the body regulate hunger and metabolism more effectively than single-hormone treatments

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In clinical trials , people taking Wegovy lost an average of 15% of their body weight over a year, significantly more than people taking a placebo

(2016) demonstrated that blocking estrogen receptor signaling abolished the suppressive effects of GLP-1R activation on reward-related behavior, further supporting the idea that estrogen is a critical modulator of GLP-1s central effects on motivated responding

These metabolites enter general amino acid pools, are filtered by the kidneys and appear in urine