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Inflammation, defective insulin signaling, and neuronal dysfunction in Alzheimers disease

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Eli Lilly reported that co-formulation of an acylated GLP-1/glucagon co-agonist with both C10 as a PE and either soybean trypsin inhibitor or soybean trypsin chymotrypsin inhibitor as protease inhibitor outperformed single-excipient approaches, achieving 1% oral bioavailability in minipigs when delivered in enteric-coated capsules (Tran et al., 2022)

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