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A: Not always
doi: 10.3748/wjg.v29.i37.5327 34
Gastrointestinal effects The most common consequence of early dosing is an increase in GI side effects
According to NICE guidance (NG28), GLP-1 receptor agonists are typically considered for type 2 diabetes when metformin is contraindicated or not tolerated, or in combination with other treatments when specific HbA1c and BMI thresholds are met
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