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PE-22-28: TREK-1 Channel Blockade# PE-22-28 (Gly-Val-Ser-Trp-Gly-Leu-Arg) is a synthetic 7-amino acid peptide derived from spadin, itself an endogenous peptide released by proteolytic processing of sortilin (neurotensin receptor-3)

The good news is that these side effects typically peak in the first 1 to 2 weeks after a dose increase and then diminish as your body adjusts

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More water = more dilute