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47,48 Moreover, active or inactive drug metabolites can influence both efficacy and adverse effects, as seen with prodrugs such as cyclophosphamide

doi: 10.3389/fendo.2017.00098 Received 18 January 2017 Accepted 18 April 2017 Published 03 May 2017 Volume 8 - 2017 Edited by Maria Felicia Faienza, Universit degli studi di Bari Aldo Moro, Italy Reviewed by Jameela Banu, University of Texas Rio Grande Valley, USA

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Provider decision is based on FDA eligibility criteria and contraindications