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These findings support the biological plausibility of a peripheral sensory contribution to GLP-1RA-associated changes in eating experience, but they do not establish that local taste-pathway modulation is sufficient to explain stable or consciously perceived alterations in flavour, food pleasure, or food-directed motivation in humans

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A critical component of successful GLP-2 therapy is gradual dose adjustments, also known as titration

This dual mechanism of action is grounded in clinical pharmacology and designed to maximize effectiveness without the risks of medication redundancy

Semaglutide shouldnt be used for people who just want to lose weight for a holiday or an upcoming event like a wedding