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Melatonin is synthesized in the pineal gland through the activation of two key enzymes: AANAT (arylalkylamine N-acetyltransferase) pCREB (phosphorylated cAMP response element-binding protein) In rat pinealocytes, Epitalon was shown to upregulate both AANAT and pCREB, suggesting a direct enzymatic stimulation of melatonin biosynthesis [56]
Holmay MJ, Terpstra M, Coles LD, Mishra U, Ahlskog M, Oz G, et al
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AIC and BIC model selection criteria were deployed to suggest which model is mechanistically important, guided by the OCR data
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