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Increased production of melanin leads to darkening of the skin, known as hyperpigmentation

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In the shallow-desensitized conformation, two cysteine crosslinks stabilize the receptors in a conformation resembling the typical desensitized state of non-KAR iGluRs

RSPO2 enhances canonical Wnt signaling to confer stemness-associated traits to susceptible pancreatic cancer cells

Nature 436:261265