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Further structural optimization delivered a large number of macrocyclic disulfides and among them 23 (HA08) encompassing a 3-homotyrosine residue in a 13-membered ring system and exhibiting the lowest Ki value in the series (Ki = 3.3 nM)
In addition, cecal RegIII and IL-33 mRNA levels were significantly higher or tended to be higher than in the control group (Fig
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It was originally discovered to be a small partial sequence of a compound that acts as a protective peptide within our gut and has a healing effect in both our upper and lower GI tract
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