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Lipids in health and disease
Citrate can be exported to the cytoplasm, where it is used as precursor for lipid biosynthesis or metabolized in the mitochondria to isocitrate by aconitase
Energy production: They contribute to maintain glycogen deposits as they can be used as fuel and therefore prevents fatigue or postpones it
Protein kinase C (PKC) and phospholipase C2 are required for Hcys inhibition of NO synthase activity, which reduces blood platelet NO generation
To test a general applicability of this mechanistic model, we confirmed our findings for the non-related enzyme PfGrx from the malaria parasite Plasmodium falciparum 18,33
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