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Vagal afferent neurons receive post-ingestive information from the GI tract through three primary mechanisms: mechanoreceptor stimulation in response to gastric distension, release of gut hormones (GLP-1, CCK, PYY et al.) triggered by the nutritional composition of consumed food, and the direct action of certain nutrients (e.g

Starting and stopping treatment because of cost or supply problems may affect hunger, weight, and side effects

If nausea is severe, hold at 4 mg for an additional 2-4 weeks before escalating

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These substances are more likely to crystallize in concentrated urine, leading to increased risk of stone formation