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the published research on the LR3 analog specifically is primarily in (a) mechanistic and pharmacokinetic studies in animals and isolated tissues, (b) cell culture applications (it is widely used as a serum-free supplement for stem cell and cell-line maintenance), and (c) analytical/anti-doping methodology (LR3 is on the World Anti-Doping Agency prohibited list)
Research has shown that reducing mitochondrial iron levels effectively reverses DIC
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Scand J Gastroenterol 31: 665-670, 1996
The mechanism involves suppression of reactive oxygen species (ROS) that the enteric nervous system uses to trigger peristaltic contractions, combined with microbiome shifts away from butyrate-producing bacteria
