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Patients received an initial dose of either 1 mg, 2 mg, or 4 mg of retatrutide and subsequent doses of either 1 mg, 4 mg, 8 mg, or 12 mg, or they received a placebo throughout the 48 weeks of the study
Nature 474, 307317
This product is intended solely for laboratory and scientific research
First, mechanistic work should integrate spatial metabolomics and mitochondrial proteomics to map ferroptosis pathways in cerebellar, spinal, and cardiac tissues from FRDA patients, with emphasis on the interaction between the ironsulfur cluster synthesis complex (NFS1ISCUISD11) and ferroptosis-related molecules (GPX4, Nrf2)
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