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Research efforts expanded throughout the 1990s and 2000s as investigators explored the peptide's potential influence on tissue repair, angiogenesis, and gastrointestinal integrity
As inflammation decreases, melanogenesis signalling may also reduce
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Results vary depending on health and lifestyle, but effects often last up to a week or more
It is therefore unsurprising that the LD 50 values for compounds 1 and 2 determined ex vivo have a similar discordance to that seen for PZQ when considering in vivo PK/PD: much like PZQ these compounds are schistosomicidal in vivo at sub LD 50 concentrations
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