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Energy levels, physical activity tolerance, sleep quality, and reduced joint discomfort were all reported at significantly higher rates in the active treatment groups compared to placebo

Relevant differences were not observed for other variables, either between non-CKD and CKD patients, or among CKD subgroups

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And some report that tirzepatide produces different GI symptoms that are equally bothersome

Hence, while -tocopherol is the most common form of vitamin E in the American diet (9), its plasma and tissue concentrations are generally significantly lower than those of -tocopherol