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Silva KC, Rosales MA, Hamassaki DE, et al

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The enzyme was dissolved in phosphate-buffered saline at pH 7.4, sterilized through a 0.22-m membrane, and administered under ultrasound guidance

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Only one study in 24 individuals, the majority of which were healthy, reported that DSIP can reduce the depth of anesthesia, increase heart rate and even reduce the intensity of delta-waves in these subjects [28]