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Finally, individuals with a history of heart failure, ischaemic heart disease, unstable angina, myocardial infarction, aortic aneurysm or dissection, stroke (ischaemic or haemorrhagic stroke), cerebral infarction, transient ischaemic attack, carotid intervention or surgery, coronary stenting, percutaneous coronary intervention (PCI) or coronary artery bypass before inclusion to the cohort or prior to the index event were also excluded

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A systematic evaluation of peripheral cytokines (e.g., via multiplex Luminex assays) will be conducted in follow-up studies to map gut-derived immune signals to CNS pathology

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