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Compared to the double-digit weight loss percentages seen in GLP-1 RA studies, phentermine appears to generate just 1-3% weight loss after six months.14 Topiramate may add a modest influence on insulin to the picture, which could account for its superior performance (at least according to an animal study).15 Topiramate studies typically see closer to 10% body weight reduction after a year of use.16 Testosterone replacement therapy (TRT) Henry offers two drugs intended to treat low testosterone: testosterone cypionate injections and testosterone cream

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Considering that systemic GLP-1R agonists and central GLP-1 appear to target different central nervous system pathways, these treatments would be expected to additively reduce food intake, which proved to be the case [74]