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Larger studies are required to ascertain long-term efficacy and safety in T1D

(The FDA has received more than 700 adverse event reports tied to compounded GLP-1s, but its not clear if the events were caused by the drugs.) The companies also see compounders as a threat to their obesity drug sales, which are estimated to balloon to $100 billion a year by 2030

Kidney Issues: There have been reports of kidney-related problems, including acute kidney injury (especially in patients who are dehydrated)