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Side effects can depend on the research model, study design, and conditions being evaluated

The SANAD II study of the effectiveness and cost-effectiveness of levetiracetam, zonisamide, or lamotrigine for newly diagnosed focal epilepsy: an open-label, non-inferiority, multicentre, phase 4, randomised controlled trial

Furthermore, activation of the kynurenine pathway promotes the production of quinolinic acid, an excitotoxic compound that promotes glutamate release and blocks glutamate reuptake (Steiner et al., 2011

This is because a fragment of the meniscus gets stuck between the bones