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[73] As noted above, the completely synthetic laboratory synthesis of B 12 was achieved by Robert Burns Woodward and Albert Eschenmoser in 1972, though this process has no commercial potential, requiring more than 70 steps and having a yield well below 0.01%

From there, maintenance is typically one injection every four to twelve weeks depending on diet, absorption and how the response holds

Huttmann K, Sadgrove M, Wallraff A, Hinterkeuser S, Kirchhoff F, Steinhauser C, et al

Kostovi I (2020) The enigmatic fetal subplate compartment forms an early tangential cortical nexus and provides the framework for construction of cortical connectivity