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In Schwann cells, Rheb gene knockdown was utilized to specifically inhibit PDH activity, which shifted the metabolic pattern towards a lactate-predominant oxidized route, thereby transporting increased lactate into peripheral axons
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High levels of IGF-1 are found in the CNS during early stages of organogenesis, which promotes brain derived growth factor (BDNF) and other neutrotropic factors that play important roles during brain development [26, 27]
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