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Curr Opin Hematol
Research showed that glucagon co-agonism increased hepatic fat oxidation and thermogenesis, providing an additional fat-loss mechanism distinct from appetite suppression alone
Results published in the New England Journal of Medicine demonstrated average weight loss of 20.9% at the 15mg dose over 72 weeks
cAMP directly activates protein kinase A (PKA) and cAMP-regulated guanine nucleotide exchange factor 2 (Epac2), that act in concert to generate downstream signals resulting in increased insulin secretion 8
CTD is inherited in an autosomal recessive manner
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