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Safety risks include immune reactions, infections at the injection site, disruptions to metabolism, effects on hormone signalling and cardiac function, and the promotion of tumour growth
The peptide has demonstrated gene-modulatory effects across 4,000+ human genes, including upregulation of collagen synthesis, stem cell markers, and antioxidant enzymes in cell culture and animal models [3]
Theoretical frameworks suggest starting tesamorelin at 1mg daily for 2 to 4 weeks before adding retatrutide, then escalating to the standard 2mg daily once tolerance is established
This increase in blood flow can also contribute to elevation of body temperature and increased sweating in response to physical exertion
PMID: 34360532
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