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Theoretically, these changes in lipid metabolism, including reductions in free fatty acid concentrations, could reduce intramyocellular lipid deposition, leading to improvements in mitochondrial function and insulin sensitivity [53, 54] that could be beneficial to skeletal muscle function

doi: 10.3390/antiox11030548 98 MinhasSBettocchiCBoeriLCapogrossoPCarvalhoJCilesizNCet al

However, both therapies can increase hepatic workload, requiring baseline liver function assessment and periodic monitoring to ensure safety

Targeting the ghrelin system to treat obesity and diabetes

GIP is another hormone that plays a role in regulating blood sugar and creating a sense of satiety