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Ibrahiem AT, Refat S, Elnaghi K, Emarah Z,Nagib RM
It was also reported that microglia are capable of removing incorrectly deposited myelin directly from the axon, contributing to the refinement of myelin sheaths, as shown in zebrafish and mice during development (Hughes and Appel, 2020
Cell surface integrin receptors on OLs such as 1 integrin interact with ECM ligands on axons to amplify growth factor signaling, regulating the survival of pre-myelinating and myelinating OLs, increasing myelin membrane formation, influencing axonal selection for myelination in an diameter-dependent manner, and regulating myelin gene translation 155,156,157,158,159,160
Blood testing is sometimes conducted but less common
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