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The 1.4% rate with Retatrutide is consistent with what would be expected from losing 24% of body weight, regardless of how the weight loss was achieved

doi: 10.1093/ajcn/86.4.1073 22 WiedemanAMBarrSIGreenTJXuZInnisSMKittsDD

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111 The only acceptable alternative endpoint in drug development, histological evidence, consists of the resolution of steatohepatitis and no worsening of liver fibrosis, or improvement in liver fibrosis of at least one stage without worsening of steatohepatitis

You have known heart disease or AFib and notice a sudden change in pattern, intensity, or associated symptoms